IS THIS STUD DOG JRD TESTED ????????.

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by bazza on 26 October 2009 - 14:10

Well put Sue b, and Frank. Actually Frank there is nothing wrong with the rose coloured glasses, I TOO POP THEM ON OCCAISIONALLY. Ah! the good old days..... gone but not forgotten.

by Videx on 26 October 2009 - 14:10

Why has nobody asked Frank (Trotters123) to obtain the DETAILS about the "EPILEPSY TEST" - after all he did write the following:

"As promised I spoke to my Vet this morning regarding the blood works. As he specified on SATURDAY! they can test for JRD but someone also asked about Epilepsy and MY Vet said Yes this can be done. Obviously the test is quite specific and he did mention that a differenct sample would be taken. So good news I think."

by Trotters123 on 26 October 2009 - 15:10

I asked my Vet

" If the blood sample taken can show JRD can it also show other disorders ie epilepsy?'

He answered

'Yes. But like all blood work it is a specific test and another sample would have to be taken.'

I think by that statement he meant that the same blood sample cannot be used for more than one test. Each carrying their own individual type of test for a different gene.
I am not a science expert by any means but I understood what he was saying.

So as far as exact details go I am not sure what you are wanting! I do not know HOW they test or what they do with the blood. Maybe someone with your extensive knowledge on blood work and testing for disorders can answer this.
All I know is what MY Vet said, you would probably have to go to your own Vet and speak to them and see what they say. MAybe you could ask more technical questions from them.

It would be so handy if this was the case that EVERYTHING could be tested this way. A simple blood sample taken at your Local Vets and 'bob's your Uncle' result in a matter of a few days. (I believe I did read somewhere that a JRD blood test was returned within a few days.....oh yes it was mentioned on this very thread!)

So that is all I can say about it at the moment as this is all my Vet told me. As well as he was unaware of the disorder with the GSD breed or rather not aware of the potential wave of carriers or sufferers. He did however say that most sufferers died either in the womb, just after birth or within a few days.

So like I promised on Saturday, I did speak to my Vet and this is what he told me.

Frank

by Sue B on 26 October 2009 - 16:10

Hi Dave, Forgive me if I sound stupid but , if as you say, "The JRD DNA test is not for specific breeds of dogs. The same test is used for all breeds of dogs", that means there will be Labs here in the UK capable of determine the existence (or not) of JRD which is actually what I thought would be the case in the first place. Then what exactly was Dogenes Inc Patenting and why exactly did they need one? This is where my confusion arose and as I am (as I admitted earlier) just a layman in my understanding of such scientitic things why I could only assume that it must have had something to do with the development of a test for a particular breed, but since this is not the case why then are JRD tests been sent off to Canada? Sorry but the logic of this simply doesnt make sense to me, hence why I thought it was perhaps more difficult to detect than other DNA markers.
Regards
Sue b

by Sue B on 26 October 2009 - 16:10

Is there a DNA test for Epilepsy or just a test once the dog has developed it?? Again another set of ????? marks as to just how far Science has developed the Canine DNA sampling.
Sue b

by Superdog on 26 October 2009 - 17:10

Hello
Can I say that the Finnish group of the European study has found a MARKER for Epilepsy. This has been done with the help of DNA.
Superdog

by Videx on 26 October 2009 - 23:10

Superdog: Please answer this question for me.
Have the Finnish Group found a DNA TEST for identifying EPILEPSY in dogs. particularly one that can DNA TEST a GSD and identify CARRIERS? - Absolute clarity is requested.

Sue, and others. I will try and answer your question. (very much simplified)

Genetic Scientists are constantly searching for the MUTATED GENES which cause diseases in dogs - these scientists can be employed in Universities, Research Centers, Private companies etc
.
When they discover the 'mutated gene' for which they may use fruit flies, or other species for this genetic research, they then have to discover a DNA TEST to detect the mutation, and establish the mode of inheritance.
They also have to protect their work, and patent it internationally, which may cost £100,000 upwards. They also require top legal specialists for much of the protection and patenting etc.

The DNA TEST once discovered is valuable, and will earn the company revenue. The company will decide if the specific DNA Test is offered under license with other organisations who may wish to offer the DNA Test to potential customers, or the test is administered through another organisation in various countries. For example Utrecht University are currently going though the patenting phase of their DWARFISM DNA Test.

When it is fully protected by patents world wide, they will then PUBLISH the test, which can be 'checked' by other organisations, but the other organisations CANNOT offer the test to the public without the license from the DISCOVERER who has patented it. Mary Whiteley discovered the JRD DNA Test (and others before that) and has now patented it and published it. Mary OWNS the JRD DNA Test, and she owns DOGenes, which she established.

If an organisation in the UK wish to offer the JRD DNA Test they can do it in one of two ways. They can agree a license arrangement with Mary, (royalties) or they can offer it by agreement with Mary, to the public, and send the 'sample swabs' to DOGenes for analysis. There is a laboratory in the UK doing the latter with the DWARFISM DNA TEST and sending all samples to UTRECHT UNIVERSITY who discovered this particular DNA Test, and the UK laboratory ADDS a premium to the price of the test. I think you will find it is around £30 more expensive than going direct to Utrecht University. Another organisation could buy all rights of a particular DNA Test for a considerable sum of money, if the 'owner' wished to sell.

It is not unknown for organisations to attempt to steal tests or related information prior to or during the patenting process. It is also not unknown for competitors searching for the same DNA Test, to try and undermine anyone who discovers it before them, I feel sure this has happened with the JRD DNA Test. Try and find those negative comments from some renowned organisations who tried to ridicule the validity of the JRD Test last year, many if not all have been 'deleted'. ALL discovered DNA tests go through a period of 2+ years to become patented and published, however it is NOT unusual for the tests to be offered to the public by the 'organisation who discovered it' similar to the Dwarfism DNA Test discovered and offered by Utrecht University, and only less than a year since its discovery.

It may surprise people to learn the commercial value and control of DNA tests, but then people are usually more shocked to find out that LIFE SAVING surgical procedures which are developed by surgeons for human operations, are also 'patented' and 'commercially valuable'.

by Videx on 27 October 2009 - 09:10

Superdog: Dorothy Cullum. Is there a DNA test for EPILEPSY?
If so, full details please.
Have one of your VET friend write your reply. This week if possible.

By the way, you can't find "markers' without DNA.
please read my last post.

by Videx on 27 October 2009 - 10:10

An interesting article:

http://www.koirangeenit.fi/index.php?Itemid=44&id=32&option=com_content&task=view

Another interesting website: EPILEPSY Resources

http://www.canine-epilepsy.com/Resources.html

by Sue B on 27 October 2009 - 12:10

Many Thanks Dave, that explains it perfectly (for me anyways) and surely clears up any misunderstandings that appear to have clouded the whole JRD issue.
Regards
Sue b

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