DM information from Dr. Coates - Page 1

I received this today from Dr. Coates:

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All we can do is the best we can using an evidenced based medicine approach. The GSDs have the same SOD1 mutation as described for the other breeds. The GSD was included in the initial study published in the Proceedings of the National Academy of Sciences. Please follow the link

http://www.pnas.org/content/early/2009/02/02/0812297106.full.pdf, to read the article. We are in the process of writing a follow up paper with information about the distribution and frequency of the mutation.

 

With regards,

 

Joan

 

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Joan R. Coates, DVM, MS, Diplomate ACVIM-Neurology

Professor, Veterinary Neurology & Neurosurgery

Department of Veterinary Medicine and Surgery

900 E. Campus Dr., VMTH-Clydesdale Hall

College of Veterinary Medicine

University of Missouri

Columbia, MO 65211

 

WOW. AWESOME.

I am very excited to hear this. This is proof based argument I can help with.

And I will add I just re-read the old article to the 2009 research link.  I must say it is not my experience in all respects, so, I wholeheartedly await what this new report says.

In case any one here wants to question why, I will also say, that I ONLY want the correct reason dogs are suffering and eventually dying from DM.

Any further explanations or requests, can be done in PM.

bump

As will I. In the meantime here is interesting information from the Chessie people. http://www.chessieinfo.net/degenerative-myelopathy.htm Sure says here it is polygentic which has never been published before. It's always been focused around a single gene mutation. The above link clearly says something more than that. I look forward to seeing the new publication. I hope it discusses this strange finding in 90% of fox terriers, a breed that has never been diagnosed with DM. Gwen

02/20009 last publication? And people complained that Dr. Clemmons never published? He was never funded by AKC/CHF. Three years and nearly 3 months later for a single even one page publication of new findings and suspicions. Seems well a bit.. Gwen

Clemmons did receive funding from the GSDCA.

Coate's contribution is the DNA test.

So now are we thinking that DM in GSD's in the same as DM in other breeds?

This is what makes no sense to me, that Clemmons recieved funding from GSDCA. It makes more sense that the Univ. of FLorida actually recieved the funding. What Clemmon's relationship with the Univ. of Florida is exactly, I have no clue, but I'm sure some of you do. My best guess would be they hired Dr. Clemmons to do research? Or he was already on the faculty? 

In which case any "discoveries" would be the intellectual property of the University. 

No I do not think DM or the mutation is the same in any breed. There may be a different mutation associated with triggering DM in each and every breed. Case point 90% of fox terriers have the SOD1 gene as published in article by Chessie group. Not one single, repeat not one single long lived fix terrier has ever been diagnosed with DM or been symptomatic of DM. Somewhat odd considering 90% of them carry this SOD1 mutation gene. If it is in fact the gene many many fox terriers would be affected with DM. Instead there are ZERO. It ain't the right gene in any breed. Period bottom line. Could be that it is actually the protective gene in some breeds. But the fact that clear, GSD's, chessie's and Berner's have come back upon necropsy with confirmed DM speaks volumes, IMO. No one needs to be thinking clear dogs are necessarily clear at this time in research. As the research is not showing that. It's only been 4 years. Not one single progeny of these breeds that are clear coming up with confirmed DM have been followed until 10+ years old. Or puppies of these dogs. They couldn't the gene was published and discovered in 2008. Too early to even come close to speculating. Gwen

The fox terriers intrigue me. My train of thought was along the lines that they may have another gene which suppresses expression of DM (who knows, I am not a geneticist ?), offering hope to halt progression by being able to switch on a particular gene in DM afflicted dogs in future. I would be the first to admit that is wild speculation on my part, but a wonderful dream nonetheless!

However to say 'it ain't the right gene in any breed' is just ridiculous unless you are a proven research scientist who has just PROVED that fact beyond a doubt. Period.

And there we are back to same old, same old. I'm done.