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by Sherman-RanchGSD on 07 March 2010 - 23:03
Enjoyed reading and learning more about this from the additional posts here on the subject. Regarding screening dna tests etc... there are many studs, breeders etc that have done it and people only need to ask when inquiring about mates, pups etc. Its a valuable tool and yes...it is no tell all. Glad we do have some tools to start with.
Debi
www.sherman-ranch.us
www.ironfistcreations.us
Debi
www.sherman-ranch.us
www.ironfistcreations.us
by Sherman-RanchGSD on 07 March 2010 - 23:03
Enjoyed reading and learning more about this from the additional posts here on the subject. Regarding screening dna tests etc... there are many studs, breeders etc that have done it and people only need to ask when inquiring about mates, pups etc. Its a valuable tool and yes...it is no tell all. Glad we do have some tools to start with.
Debi
www.sherman-ranch.us
www.ironfistcreations.us
Debi
www.sherman-ranch.us
www.ironfistcreations.us
by Mark3 on 08 March 2010 - 01:03
Fred Lanting as of 21 Feb 2010
‘Following a literature search for diseases in other species with clinical and pathological similarities to CDRM, a working hypothesis was established: CDRM is caused by a CAG trinucleotide repeat expansion in an unknown gene. A number of molecular biological techniques were employed to test this theory, including the Repeat Expansion Detection (RED) technique. This work is still in progress but there is some evidence, still inconclusive, that CDRM may be the result of a trinucleotide repeat expansion. Undoubtedly, CDRM has a complex aetiology which probably involves several different factors but most authors agree there is almost certainly a genetic factor due to the very high incidence of the disease in one breed. [The results from the Glasgow experiments provided some evidence that CDRM is principally genetic, and specifically of an “expansion” as noted, in the CAG nucleotide sequence on a gene that yet has to be found or marked.]’
www.fredlanting.org/2010/02/the-new-knowledge-of-dm-%E2%80%9Cgsd-myelopathy%E2%80%9D/
‘Following a literature search for diseases in other species with clinical and pathological similarities to CDRM, a working hypothesis was established: CDRM is caused by a CAG trinucleotide repeat expansion in an unknown gene. A number of molecular biological techniques were employed to test this theory, including the Repeat Expansion Detection (RED) technique. This work is still in progress but there is some evidence, still inconclusive, that CDRM may be the result of a trinucleotide repeat expansion. Undoubtedly, CDRM has a complex aetiology which probably involves several different factors but most authors agree there is almost certainly a genetic factor due to the very high incidence of the disease in one breed. [The results from the Glasgow experiments provided some evidence that CDRM is principally genetic, and specifically of an “expansion” as noted, in the CAG nucleotide sequence on a gene that yet has to be found or marked.]’
www.fredlanting.org/2010/02/the-new-knowledge-of-dm-%E2%80%9Cgsd-myelopathy%E2%80%9D/
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