http://www.canada.com/victoriatimescolonist/story.html?id=67f15c17-2717-4022-bb76-1b982456e793&k=94653
Many authors of the myostatin studies have speculated that interfering with the activity of myostatin in humans may reverse muscle wasting disease associated with muscular dystrophy, AIDS and cancer. Some predict that manipulation of this gene could produce heavily muscled food animals. Indeed, current research is underway to investigate and develop these potentialities. Sure enough, a large pharmaceutical company has recently applied for a patent on an antibody vaccination for the myostatin protein.
A medical doctor and author of weight training articles asserts that overexpression of myostatin is to blame for weight lifters that have trouble gaining muscle mass. The spokesperson for a supplement and testing lab erroneously implied that the "rarest" form of mutation in the myostatin gene is responsible for a top competitive bodybuilder's massive muscle gains, not taking into account the performance-enhancement substances the bodybuilder may be using. The public media has, of course, predicted that "steroid-popping" athletes will take advantage of myostatin inhibitors to gain competitive edge (3).
Many of these assertions are unfounded or they misrepresent the science. Granted, the possibility exists that manipulation of the myostatin gene in humans may be a key to reversing muscle-wasting conditions. However, too little is still yet unknown regarding myostatin's role in muscle growth regulation. It is imperative that research demonstrates that the loss of myostatin activity in adults can cause muscle tissue growth. Likewise, research must also prove that overexpression or administration of myostatin causes loss of muscle mass. Also important is to know if manipulation of myostatin will interfere with other growth systems, especially in other tissues, and result in abnormal pathologies. Although McPherron's gene knockout mice did not experience any other gross abnormalities, mice are not humans.
We do not fully understand the roles of myostatin in exercise-induced muscle hypertrophy or regeneration following muscle injury. Until we do, it may be premature to blame the lack of hypertrophy in weightlifters on overexpression of myostatin. Nor does the research support the claim that a top bodybuilder's muscle mass gains are resultant of a detected mutation in the myostatin gene. The research simply does not advocate blaming genetic myostatin variations as a source of significant differences in human phenotypes.
Considering the history of the athlete's propensity, in the public eye, to abuse performance-enhancement substances, the media's prediction of myostatin-inhib
http://www.canada.com/victoriatimescolonist/story.html?id=67f15c17-2717-4022-bb76-1b982456e793&k=94653
Many authors of the myostatin studies have speculated that interfering with the activity of myostatin in humans may reverse muscle wasting disease associated with muscular dystrophy, AIDS and cancer. Some predict that manipulation of this gene could produce heavily muscled food animals. Indeed, current research is underway to investigate and develop these potentialities. Sure enough, a large pharmaceutical company has recently applied for a patent on an antibody vaccination for the myostatin protein.
A medical doctor and author of weight training articles asserts that overexpression of myostatin is to blame for weight lifters that have trouble gaining muscle mass. The spokesperson for a supplement and testing lab erroneously implied that the "rarest" form of mutation in the myostatin gene is responsible for a top competitive bodybuilder's massive muscle gains, not taking into account the performance-enhancement substances the bodybuilder may be using. The public media has, of course, predicted that "steroid-popping" athletes will take advantage of myostatin inhibitors to gain competitive edge (3).
Many of these assertions are unfounded or they misrepresent the science. Granted, the possibility exists that manipulation of the myostatin gene in humans may be a key to reversing muscle-wasting conditions. However, too little is still yet unknown regarding myostatin's role in muscle growth regulation. It is imperative that research demonstrates that the loss of myostatin activity in adults can cause muscle tissue growth. Likewise, research must also prove that overexpression or administration of myostatin causes loss of muscle mass. Also important is to know if manipulation of myostatin will interfere with other growth systems, especially in other tissues, and result in abnormal pathologies. Although McPherron's gene knockout mice did not experience any other gross abnormalities, mice are not humans.
We do not fully understand the roles of myostatin in exercise-induced muscle hypertrophy or regeneration following muscle injury. Until we do, it may be premature to blame the lack of hypertrophy in weightlifters on overexpression of myostatin. Nor does the research support the claim that a top bodybuilder's muscle mass gains are resultant of a detected mutation in the myostatin gene. The research simply does not advocate blaming genetic myostatin variations as a source of significant differences in human phenotypes.
Considering the history of the athlete's propensity, in the public eye, to abuse performance-enhancement substances, the media's prediction of myostatin-inhib
Considering the history of the athlete's propensity, in the public eye, to abuse performance-enhancement substances, the media's prediction of myostatin-inhibitor may or may not be warranted. We all know that today's athletic arena demands gaining the competitive edge to maintain top level competition. For many athletes, that is accomplished by supplementing hard training with substances that enhance growth or performance. Whether or not myostatin inhibitors will be added to the arsenal of substances is difficult to predict. Until science reveals the full nature of this growth factor and its role in the complex regulation of muscle tissue, and researchers determine its therapeutic implications, we can only surmise. Despite attempts to tightly control any pharmaceutical uses of myostatin protein manipulation, they will likely surface at some point in the black market world of bodybuilding supplements. Let us hope that science has determined the side effects and the benefits by that point
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One breed of cattle that was described to us as myostatin is the Belgian Blue. We talked to a breeder and that's the explanation she gave us. Check these guys out. http://www.mnpfarm.com/photo_gallery.html I don't think I would like a myostatin GSD.
Cloneing will be the next thing on the list,,,,,,wonder what a cloned gsd would look like.,.,
This thread is coming up lopsided and wrong on the screen a Myostatin goof UP??????lol
eghad! This thread is so freakin' hard to read....my eyes are shot.
But, I'm with you Animules...no way would I like to see a myostatin GSD... The cattle looked scarey enough.
The Belgian Blue we saw really caught our eyes! Here's a picture of another one.
http://fig.cox.miami.edu/~cmallery/150/neuro/belgian.blue.jpg
A cloned GSD would look like whoever it was cloned from. Many animals getting cloned now, including Skipper the barrel racing horse. Ahhh, for another Secratariet.
good grief!
I'd hate to see that thing stampeding my way!
i agree with others - i do not want to see or meet a myostatin gsd! those bulls are grotesque!
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