ISOXAZOLINES for veterinary use in DOGS against fleas and ticks - Page 1

The isoxazolines approved for veterinary use so far are the following:

• Afoxolaner: used on dogs against fleas, and some ticks species (NEXGARD from MERIAL).
• Fluralaner: used on dogs against fleas, and some ticks species (BRAVECTO from MERCK ANIMAL HEALTH).
• Sarolaner: approved in the EU as an oral tablet for dogs against fleas, & ticks,and certain mites. (from ZOETIS).

These products have the same mode of action as macrocyclic lactones ( moxidectin, ivermectin, milbemycin oxime, etc. ) and will likely have a similar pattern of adverse effects.  In the studies published for Sarolaner the side effects and neurologic symptoms were the same as those for macrocyclic lactones.  Almost all of the studied test subjects were beagles and puppies did not tolerate Sarolaner well so toxicity based on breed sensitivity and age can be expected.

http://parasitipedia.net/index.php?option=com_content&view=article&id=2668&Itemid=2951

mode of action ... Isoxazolines with insecticidal and tickicidal efficacy are non-competitive GABA (gamma-aminobutyric acid) receptor antagonists, much more selective for GABA receptors in insects or ticks, than for those in mammals, including humans. They bind to chloride channels in nerve and muscle cells, which blocks the transmission of neuronal signals. Affected parasites are paralyzed and die.

Many of the older flea, tick and wormer products are off patent or will be soon so the big Pharma companies are bringing out "new" products with patent protection that do the same thing at a higher price than they can charge for their older products facing generic competition.