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by Mithuna on 10 July 2015 - 16:07
My dog has been put on a 10 day antibiotic course ( clavamox 375 mg twice daily) for a small abscess from a s suspected piece of bone than injured her inner lip. However, she is alos on a regular ( every 30 days ) Sentinel Spectrum Preventitive. She is like 5 days into the antibiotics but in 3 days the 30 day cycle for giving the sentinel will begin again. Should she be getting the Sentinel Spectrum, even though she is still on the antibiotic course? Of course I can call the vet, but what are the learned opinions on here?

by Mithuna on 11 July 2015 - 00:07
Hvae the experts abandoned me?

by Jenni78 on 11 July 2015 - 01:07
I've never heard of a contraindication between monthly flea/tick/heartworm poisons and antibiotics, but I'd not give Sentinel to begin with, so I'm probably not the expert you'd want to ask. But I see no other experts stepping forward. Hmmm.
I would make sure to give a strong probiotic during and after this time, or you'll likely be dealing with yeast issues down the road.
by joanro on 11 July 2015 - 01:07
If it was my dog, I'd get rid of the poison, skip the heartworm preventative this month, give your dog time to detox while on the antibiotics. Start up on ivermnectin next month...tell your vet to take the sentinal himself if he insists on you giving it to your dog.
by hexe on 11 July 2015 - 03:07
While it isn't my preferred HW preventative product, when Interceptor became unavailable I elected to use the basic Sentinel Flavor Tabs as the least of the available 'evils', so to speak. There are no published contraindications for the administration of Sentinel at the same time as any antimicrobials, so I wouldn't defer dosing of either one--and remember, always, NEITHER product should be given on an empty stomach.
joanro, there are two varieties of Sentinel available--the basic version that is only milbemycin oxime and lufenuron, and the Sentinel Spectrum version that adds praziquantel to the mix; it's the milbemycin oxime itself that is effective in preventing hook-, whip- and roundworm infestations, in addition to heartworm, so I have no problem with getting that additional benefit from my dog's heartworm preventative. Now that Interceptor is again available, I'll be switching back to that once I've used up my supply of the Sentinel, however, because I don't like using a flea-control product that's given orally [and in the case of the lufenuron, it's only an Insect Development Inhibitor and interferes with production of a next generation--has no effect at all on adult fleas]. To be honest, I wish the daily dosed HW product, diethylcarbamazine citrate [Caracide, Filaricide, Filaribits, etc.] was still readily available, as it has less effect on the animal's immune system than the monthly preventatives--that's the reason it was the heartworm preventative of choice for dogs with degenerative myelopathy.

by Jenni78 on 11 July 2015 - 04:07
I had a dog with a terrible reaction to milbemycin...I have a thing against it now. It was very scary and the damage lasted quite a while.
by hexe on 11 July 2015 - 06:07
That's really unusual, Jen, since milbemycin has the least reported adverse reactions of any of the heartworm preventative products--at least it did until it become available as a generic pharmaceutical and started to be combined with other anti-parasitics and marketed by other companies under other trade names--but there will always be those individuals who respond badly to a product that most others tolerate without any concerns or issues, no matter what type of product is involved. I certainly can understand why that experience would put you completely off of ever using a milbemycin product again, too!
I've had good results with Interceptor since I began using it around two years after it first came on the market--I rarely, if ever, use a product that's been out less than a year or two; it's a habit I picked up from the first vet I worked for, waiting while a new product is used in the real population, under non-controlled conditions, and observing the reports that come back as to pros and cons before using it for our own pets or dispensing it to those of our clients. If the basic Sentinel product wasn't on the market when Interceptor's production stopped, I probably would have gone back to an ivermectin-based HW preventative, but so far I've not had any issues with it, even in my senior guy who has discoid lupus. Hopefully that continues, since I've got another 18 months worth of product on hand to go through!
by joanro on 11 July 2015 - 12:07
by joanro on 11 July 2015 - 12:07
Sorry, hexe, it just struck me funny.:-)

by Jenni78 on 11 July 2015 - 16:07
It was not a GSD, Hexe. It was my old Chihuahua. Liver issues immediately.
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