Ivomec and mating - Page 1

Just want to know "how many days interval between administration of ivomec and actual breeding/mating is considered safe? I admininistered ivomec and shortly after my bitch came in heat to my amazement, and so i'm curious, if it will interfere or inhibit conception, since i'll possibly breed her 16 days after ivomec administration. I've been using ivomec but hadn't the guts to use it this close or when breeding's by the corner. Any precise/related expirience out there? Is welcomed.

what dosage are you using?

Sorry, i left office for sometime. She was given .05 ml.

Sorry, i left office for sometime. She was given .05 ml.

FYI......

http://www.dogaware.com/health/ivomec.html

 

Liquid ivermectin (Ivomec) is available in 1% injectable solution for treating cattle and pigs, and in 0.08% oral solution for treating sheep (the 0.27% solution has been discontinued). In most cases, you will need a syringe (no needle) that measures to the tenth of a cc to administer. Note that all of these products are given orally.

Ivermectin 0.08% solution made for sheep can be used undiluted. An 8 oz (236 ml) bottle of ivermectin 0.08% solution costs around $28, and would be enough to treat 70,000 pounds of dogs.

Ivermectin 1% solution is more readily available but cannot be used undiluted even for very large dogs. Without diluting the ivermectin solution, the amount to give is too small to measure accurately. The proper way to use liquid 1% ivermectin solution for dogs is to dilute the ivermectin with propylene glycol (or possibly food-grade (USP) glycerin -- I have not actually seen instructions using glycerin rather than propylene glycol, but liquid ivermectin injectable solutions are made with 40% glycerol and 60% propylene glycol). Some people have used vegetable oil instead because it tastes better and is easier to get, but the drug will not mix as well with oil and so the dosage within the solution may not be even. A 50 ml bottle of ivermectin 1% solution costs around $35 and would be enough to treat 150,000 pounds of dogs. There are instructions below for creating a 30:1 dilution, which works best for small dogs and can also be used for large dogs, and also instructions for creating a 9:1 dilution.

 

Heartgard Blue for dogs up to 25 pounds has 68 mcg ivermectin
Heartgard Green for dogs 26-50 pounds has 136 mcg ivermectin
Heartgard Brown for dogs 51-100 pounds has 272 mcg ivermectin

Keep Ivomec and any unused mixture refrigerated. The length of time the diluted mixture will remain potent is unknown.

How the calculations were done
Heartgard dosage is a minimum of 6 mcg/kg (2.72 mcg/lb). Note that dogs at the lower end of the weight ranges get twice this much, or even more for very small dogs. Ivermectin has a very wide safety range; dosage for dogs with demodex is 300 mcg/kg, and this amount may be given daily over weeks or months. It's important not to underdose your dog, which may not be effective at preventing heartworms. Always round up when calculating dosage.

Ivomec 1% solution:
1 cc of ivomec 1% contains 10,000 mcg ivermectin; 0.1 cc = 1,000 mcg ivermectin
1 cc of ivomec 1% diluted 9:1 contains 1,000 mcg ivermectin; 0.1 cc = 100 mcg ivermectin.

The exact dosage is 0.0272 ml per 10 pounds of body weight, approximately 0.03 cc per 10 pounds of body weight.

1 cc of ivomec 1% diluted 30:1 contains 333 mcg ivermectin; 0.1 cc = 33 mcg ivermectin.

The minimum dosage is 0.0824 cc per 10 pounds of body weight, approximately 0.1 cc per 10 pounds of body weight.
 

Ivomec 0.08% sheep drench solution:
1 cc of ivomec 0.08% sheep drench solution contains 800 mcg ivermectin; 0.1 cc = 80 mcg ivermectin.
The minimum dosage is 0.034 cc per 10 pounds of body weight, approximately 0.1 cc per 30 pounds of body weight.
 

Ivermectin Powder for swine:
5 grams of ivermectin power contain 1,000 mcg ivermectin
1 gram of ivermectin powder contains 200 mcg ivermectin

The minimum dosage is 0.136 grams per 10 pounds of body weight.

The company says that 1 teaspoon weighs 5 grams, but people who have weighed a level teaspoon of the powder have found that it weighs 2.8 grams. Based on this information:
1 level teaspoon (2.8 grams) of ivermectin powder contains 560 mcg ivermectin
1/4 tsp (0.7 grams) of ivermectin powder contains 140 mcg ivermectin
Give 1/4 tsp per 50 pounds of body weight.

Measurement notes:
1 drop is approximately 0.05 cc
cc is the same as ml
Note that you should always round the dosage up, not down. It's fine to give a little more than is needed, but if you give less, your dog may not be protected.

For the most part, larger dosages are safe, as long as your dogs are not infected with heartworms (in which case, very high doses may kill off too many microfilariae at once, which can lead to an anaphylactic reaction), or if your dogs have the mutation that makes them more susceptible to ivermectin. Even then, as long as you're close to the dosage above, you should be fine, it's just when you give 10 times as much as you should or more that you might run into trouble. This is quite common if you follow recipes on the internet, which often leave out the fact that the ivermectin must first be diluted 9:1 with another liquid, making the dosage ten times what it should be.

http://web.archive.org/web/20061104194714/http://www.heartwormsociety.org/katrina.htm
"Be careful when calculating doses and administering ivermectin solution, as the concentration in most available solutions is very high compared to the dose needed for small animal treatment. Remember 1% solution = 1 gram/100 ml = 10 mg/ml = 10,000 ug/ml [ug=mcg]. . . . People often dilute 1% solution with 99 mls of propylene glycol [dilution ratio of 99:1], to create a solution that is 100 micrograms per ml. The preventive dose of ivermectin for a 10 kg [22 lb] dog then would be .5 mls."

http://www.espomagazine.com/vet/apr96.htm
"As mentioned in that article, the dose of Ivermectin necessary to treat or prevent intestinal parasites is about 30 times the dose used to prevent heartworm disease. The dosage you listed, 0.1 cc per 10 pounds of body weight, is the dosage recommended for the prevention of intestinal parasites and heartworms [thus, it's 30 times higher than needed to prevent heartworms alone]. Therefore, if you wish to use the cattle wormer, Ivomec, as a heartworm preventative only, the amount needed would, indeed, be too minute to measure accurately. One way to solve the problem is to dilute a small amount of Ivomec in vegetable oil or propylene glycol (a solvent sometimes used to treat bloat in livestock). The vegetable oil tastes better, but the drug will mix better with propylene glycol because that is the same liquid used to dissolve the Ivermectin in a bottle of Ivomec.
"One dilution scheme which would minimize waste would involve using a 1 cc syringe and the more common 3 cc syringe. Draw up 0.1 cc of Ivomec., using the small syringe, and mix well with 3 cc of vegetable oil or propylene glycol [this is a dilution ratio of 30:1]. Using this diluted product, the heartworm preventative dose would be a familiar 0.1 cc per 10 pounds of body weight. A larger amount could be diluted and stored in the refrigerator for future use, but the length of time its potency would remain is unknown."

http://www.ncbi.nlm.nih.gov/pubmed/3434921

study on ivermec and pregnancy in dogs........

http://www.pedigreedatabase.com/german_shepherd_dog/forum.read?mnr=177909&pagen=1

here's a discussion about it........




with correct dosage, its considered safe for pregnant dogs.