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by gsm44 on 21 November 2010 - 21:11
Vet has started prescribing Milbemax worming tablets instead of Drontal.
Gave my female 2 tablets on Saturday and she has been withdrawn and off her food since.
Noticed half her stools were orange this morning.
Having a look on the internet it seems there are some side effects with Milbemax.
Anyone with similar experiences?
Gave my female 2 tablets on Saturday and she has been withdrawn and off her food since.
Noticed half her stools were orange this morning.
Having a look on the internet it seems there are some side effects with Milbemax.
Anyone with similar experiences?
by Doppelganger on 22 November 2010 - 12:11
Milbemax contains macrocyclic lactones, which can be fatal to some dogs, particularly collie breeds and there is a DNA test for MDR1 which tells if they are likely to be affected.
I would not use Milbemax on any breed. The vets get a good deal from the reps for promoting it and when I sent some dogs to Finland last year my vet allowed me to buy the Drontal online myself and he let me take them in to him to administer for the pet passport travel regulations. I have an article about Milbemax somewhere which I will look up.
I would not use Milbemax on any breed. The vets get a good deal from the reps for promoting it and when I sent some dogs to Finland last year my vet allowed me to buy the Drontal online myself and he let me take them in to him to administer for the pet passport travel regulations. I have an article about Milbemax somewhere which I will look up.
by Doppelganger on 22 November 2010 - 12:11
Multidrug Sensitivity (e.g. ivermectin)
Some breeds of dogs are more sensitive to certain drugs compared to other breeds. For example, Collies, Australian Shepherds and other breeds are often more sensitive to the antiparasitic drug, ivermectin. ←
Why are some breeds more sensitive to the effects of drugs than other breeds? Which drugs have been reported to cause problems? At Washington State University's College of Veterinary Medicine you can get your dog tested for drug sensitivity and keep up with the latest research.
The main sections of the VCPL web site are listed on the navigation menu at your left. Click on a link to visit that section of the VCPL web. The current page is highlighted in crimson.
It is well known that Collies and related breeds can have adverse reactions to drugs such as ivermectin, loperamide (Imodium¿®), and others. It was previously unknown why some individual dogs were sensitive and others were not. Advances in molecular biology at the Veterinary Clinical Pharmacology Laboratory at Washington State University's College of Veterinary Medicine have led to the discovery of the cause of multi-drug sensitivity in affected dogs. The problem is due to a mutation in the multi-drug resistance gene (MDR1). This gene encodes a protein, P-glycoprotein, that is responsible for pumping many drugs and other toxins out of the brain. Dogs with the mutant gene can not pump some drugs out of the brain as a normal dog would, which may result in abnormal neurologic signs. The result may be an illness requiring an extended hospital stay--or even death.
A test has recently been developed at Washington State University to screen for the presence of the mutant gene*. Instead of avoiding drugs such as ivermectin in known susceptible breeds, veterinarians can now determine if a dog is normal, in which case the drug can be administered or abnormal, in which case an alternative treatment can be given.
Owners and breeders can submit samples for testing. All that is needed for the test is a cheek brush sample that can be obtained by the owner and sent by mail for analysis.
Affected Breeds
Approximately 3 of every 4 Collies in the United States have the mutant MDR1 gene. The frequency is about the same in France and Australia, so it is likely that most Collies worldwide have the mutation. The MDR1 mutation has also been found in Shetland Sheepdogs (Shelties). Australian Shepherds, Old English Sheepdogs, German Shepherds, Long-haired Whippets, Silken Windhounds, and a variety of mixed breed dogs.
The only way to know if an individual dog has the mutant MDR1 gene is to have the dog tested. As more dogs are tested, more breeds will probably be added to the list of affected breeds.
Some breeds of dogs are more sensitive to certain drugs compared to other breeds. For example, Collies, Australian Shepherds and other breeds are often more sensitive to the antiparasitic drug, ivermectin. ←
Why are some breeds more sensitive to the effects of drugs than other breeds? Which drugs have been reported to cause problems? At Washington State University's College of Veterinary Medicine you can get your dog tested for drug sensitivity and keep up with the latest research.
The main sections of the VCPL web site are listed on the navigation menu at your left. Click on a link to visit that section of the VCPL web. The current page is highlighted in crimson.
It is well known that Collies and related breeds can have adverse reactions to drugs such as ivermectin, loperamide (Imodium¿®), and others. It was previously unknown why some individual dogs were sensitive and others were not. Advances in molecular biology at the Veterinary Clinical Pharmacology Laboratory at Washington State University's College of Veterinary Medicine have led to the discovery of the cause of multi-drug sensitivity in affected dogs. The problem is due to a mutation in the multi-drug resistance gene (MDR1). This gene encodes a protein, P-glycoprotein, that is responsible for pumping many drugs and other toxins out of the brain. Dogs with the mutant gene can not pump some drugs out of the brain as a normal dog would, which may result in abnormal neurologic signs. The result may be an illness requiring an extended hospital stay--or even death.
A test has recently been developed at Washington State University to screen for the presence of the mutant gene*. Instead of avoiding drugs such as ivermectin in known susceptible breeds, veterinarians can now determine if a dog is normal, in which case the drug can be administered or abnormal, in which case an alternative treatment can be given.
Owners and breeders can submit samples for testing. All that is needed for the test is a cheek brush sample that can be obtained by the owner and sent by mail for analysis.
Affected Breeds
Approximately 3 of every 4 Collies in the United States have the mutant MDR1 gene. The frequency is about the same in France and Australia, so it is likely that most Collies worldwide have the mutation. The MDR1 mutation has also been found in Shetland Sheepdogs (Shelties). Australian Shepherds, Old English Sheepdogs, German Shepherds, Long-haired Whippets, Silken Windhounds, and a variety of mixed breed dogs.
The only way to know if an individual dog has the mutant MDR1 gene is to have the dog tested. As more dogs are tested, more breeds will probably be added to the list of affected breeds.
by Doppelganger on 22 November 2010 - 12:11
by Wildmoor on 23 November 2010 - 11:11
www.laboklin.co.uk/laboklin/showGeneticTest.jsp
www.laboklin.de/index.php
MDR1-Gendefekt (Ivermectin-Überempfindlichkeit)*
by AmbiiGSD on 23 November 2010 - 12:11
My vet has also swapped from Drontal to Milbemax.
I've gone over to Panacur, as I was informed when I got the Cattle Dog that there have been incidents with Cattle Dogs and Drontal that mirror the Ivermectin/collie blood brain barrier crossing.
The vet and I went through the drug books, cross referencing the concoctions that they load into wormers, and the only safe option we believed was to go to a different drug entirely. Hence the panacur.
Even so I worm as little as possible, once a year from the age of 1 or if it is deemed neccasary.
The less chemicals we pump into our dogs the better.
p.s
You might want to try Lopatol, I haven't used it for years but it's not as severe as some of the more powerful wormers, thus not quite as effective, if you are dealing with a worm burden but it does the job if it's prevention more than cure.
I've gone over to Panacur, as I was informed when I got the Cattle Dog that there have been incidents with Cattle Dogs and Drontal that mirror the Ivermectin/collie blood brain barrier crossing.
The vet and I went through the drug books, cross referencing the concoctions that they load into wormers, and the only safe option we believed was to go to a different drug entirely. Hence the panacur.
Even so I worm as little as possible, once a year from the age of 1 or if it is deemed neccasary.
The less chemicals we pump into our dogs the better.
p.s
You might want to try Lopatol, I haven't used it for years but it's not as severe as some of the more powerful wormers, thus not quite as effective, if you are dealing with a worm burden but it does the job if it's prevention more than cure.
by missbeeb on 23 November 2010 - 13:11
Drontal nearly killed one of my old dogs some years back. The locum that I saw (when Jack was so poorly) told me it was the wormer and wrote as much in his letter to my regular Vet.
I 'phoned the makers first thing on the Monday... I was astounded at their reaction. No surprise, no problem, asked for my bank a/c details and refunded me all my Vet fees etc! Of course I asked why one dog had been affected like this when the others were fine... "probably because he's old, they can react badly," she said. Why aren't we given this info on the packaging, I asked... "your Vet is given all the literature," was her response.
Yes! I ranted on that "WE" should have that info on the medication that "WE" pay for. Had I known that there was even a small chance of it making Jack ill, I'd NEVER have given him the damn stuff!
I don't worm my dogs often either Ambi, I'm lucky that I've never had a scavenger, so I don't feel that I need to worm more than once a year. I don't use Flea products on mine either. I do spray the whole house and I've never had a problem.
These toxins that we pay through the nose for, do more damage to our animals than we're told about. The Veterinary profession, in conjunction with pharmaceutical companies, covers up a lot.
Then we have vaccines.............
by Lief on 24 November 2010 - 09:11
milbemyicin is commmonly used as the main drug in iterceptor and sentinel to prevent heartworm and hooks and is considered safe and effective and well tolorated even in off label dosed the only reason I could see adding the droncit would be if you have a chronic tapeworm problem which it seems would be easier to get the fleas under control than continually worm for tapes..I haven't seen a tapeworm in years
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