Renal insufficiency in young dog? - Page 1

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by oso on 05 March 2008 - 15:03

I am writing on behalf of someone who bought two females from my kennel. I saw both these dogs last august, the older one was beautiful and in prime condition but I was shocked to see the younger puppy. The first thing I noticed was that she had a distended abdomen - she looked pregnant although only 8 months old at the time. Her coat was dull and despite the swollen abdomen she was thin. Her temperment had also changed, from being a very dominant outgoing puppy wih lots of drive she now seemed lethargic, unwilling to play and even slightly nervous. I told the owners there was something wrong and to have her checked out. I did not hear from them again until yesterday when they came round to say that since we last spoke they have seen 3 different vets, had many tests done as well as treatment, including diuretics and antibiotics, but the problem has not resolved. The latest vet diagnosed chronic renal insufficiency. We are not in the US and do not have very sophisticated veterinary care available. They are wondering about euthanaisia. I do not know what to recommend as I have had no experience of this condition. I do not have any details of the tests that have been carried out, or the treatment attempted so far, but wonder if anyone here has any experience of anything similar?

CaptMike

by CaptMike on 05 March 2008 - 16:03

They need t' be lookin' into gettin' this GSD Lassy on t' Anabolic Androgenic Steroid, Deca-Durabolin Aye! T' lassy will not come into season on t' AAS as well.


Rezkat5

by Rezkat5 on 05 March 2008 - 23:03

Has she/he been tested for Lyme Disease?

 

 


by gsdlvr2 on 06 March 2008 - 00:03

 Renal insufficiency can happen in a young dog sadly. When I hear distended abdomen I think liver not kidneys. Have they checked that? Either way, I don't think the future is bright for the young one. Temperament change could be kidneys or liver or many other things. Even in a country without sophisticated medical tools the vet should be able to percuss the abdomen to check the liver for fluid and palpate if the border is enlarged but if there is alot of fluid the border can be difficult to palpate even for a good vet which in and of itself should be diagnostic to some degree.Diuretics and antibiotics won't help if it's the liver but diuretics should help if it was kidneys. IMO i'm not a vet.

if you could get any details of the tests done or the blood work done it would help us to help your friend.


Videx

by Videx on 06 March 2008 - 00:03

CHECK THIS OUT
JUVENILE RENAL DYSPLASIA (JRD) DNA TESTING
Discovery of the Mutation and development of a direct DNA test for JRD
by Dr. Mary H. Whiteley, Ph.D. - DOGenes Inc.
Read the article here

http://www.videxgsd.com/juvenile_renal_dysplasia_DNA_test.htm

THIS SHOULD INTEREST ALL GSD BREEDERS


Rezkat5

by Rezkat5 on 06 March 2008 - 01:03

And yes I agree, the future does not look bright for this young one.

The reason I mentioned Lyme Disease, is that if you are in a big Lyme disease area.  A dog being positive for Lyme Disease can cause renal failure.  And from what I've seen where Lyme disease does cause this, the outlook is very very very very poor.  We see a lot of Lyme disease where I work, mostly in the unvaccinated dogs for Lyme.  And a few, and only a very few go into Renal failure and it's very very sad, because there's really nothing that can be done at that point. 


CaptMike

by CaptMike on 06 March 2008 - 03:03

Aye! if ye take t' GSD lassy to a University Vet College in t' US, they would be very knowledgable about the use of "Deca Durabolin"(nandrolone decanoate) regarding renal failure in Canines.  Your Vet should be able to find info and aquire t' drug easily aye. Me would give t' lassy 25mg per week for 6wks to start and then assess from there. Ye might even be able to get it at a Pharmacia. Me don't know t' laws or customs of ye country aye.

http://www.articlesltd.net/Article/Live-a-physically-active-life-with-Nandrolone-decanoate/1907

 


by oso on 06 March 2008 - 13:03

Thank you so much for all the replies. I did talk to my own vet about this last night and as gsdlvr has mentioned he also suspected it could be a liver issue, in which case he thought treatment may be possible. However, he said that if it is definitely renal failure there was very little that could be done for her. He also mentioned that there would be many possible causes for this to occur, Videx, thanks, I actually noticed your article just after I had posted my message yesterday, quite a coinicidence really as it does not seem to be something that crops up a lot in GSD literature... Rezkat, Lyme¿s disease has been known to occur here (Ecuador) but it is not common and also known mainly on the coast (we are in the mountains). Capt. Mike, I will investigate your suggestion, we can buy drugs at the Farmacias here, but not sure if this will be available. The next thing I plan is to get copies of all the tests done so far so I can get a better idea of what can be ruled out. Once again thanks for all your input.

by gsdlvr2 on 06 March 2008 - 20:03

 oso if it is the liver and not the kidneys the steroids CaptMike mentioned would be harmful because they are metabolized by the liver. Please post the lab results when you get them.


CaptMike

by CaptMike on 06 March 2008 - 22:03

In t' original post it was posted "diagnosed chronic renal insufficiency"......If several tests were performed, weren't common blood tests performed?aye Were HDL/LDL done?  A low plasma cholesterol level is indicative of severe liver disease. aye MCV (Mean Corpuscular Volume) A decrease in MCV would then indicate that t' RBC's are abnormally large(or macrocytic), and this may be an indicator of iron deficiency anemia or thalassemia. When an increase is noted, that would indicate abnormally small RBC (microcytic), and this may be indicative of a vitamin B12 or folic acid deficiency as well as liver disease. Glucose aye, Increased levels can be indicative of  chronic renal failure, Aye! BUN (Blood Urea Nitrogen)
This test measures t' amount of urea nitrogen that's present in t' blood. When protein is metabolized, t' end product is urea which is formed in t' liver and excreted from the bloodstream via the kidneys. This is why BUN is a good indicator of both liver and kidney function. aye Bilirubin, Bilirubin is one of t' many constituents of bile, which is formed in the liver. An increase in levels of bilirubin can be indicative of liver stress or damage/inflammation. AST (Aspartate Aminotransferase, previously known as SGOT) This is yet another enzyme that's used to determine if there's damage or stress to the liver. Aye! if ye canine has liver problems ye should give, Milk Thistle, ALA (Alpha Lipoic Acid), and  Liv-52 .

The ultra safe Deca injectable is (naturally) put right into the animal's (dog or human) bloodstream and only undergoes a far less extensive second pass metabolism. Aye! Proper dosage poses no problem to t' liver.

 

Reported Characteristics

  • Pharmaceutical Name:Nandrolone Decanoate
  • Chemical Name:19-nor-testosterone
  • Cutting/Bulking:Both
  • Anabolic Rating: 125
  • Active-Life: 14-16 days
  • Drug Class: Anabolic/Androgenic steroid
  • Average Reported Dosage: Men 400-600mg weekly,  Women 50-100mg weekly
  • Acne: Possible
  • Water Retention: Some
  • Decreases HPTA function: Severe
  • High Blood Pressure: No.
  • Aromatization: Low, converts to less active norestrogens
  • Liver Toxic: No
  • DHT Conversion: No, converts to NOR- DHT
  • Noted Comments: Highly anabolic/moderate androgenic effects
  • Average Price: 10/amp

Nandrolone Decanoate is a very anabolic and slightly androgenic form of 19-nortestosterone A very prominent positive nitrogen balance is realized with administration of this product. And since nandrolone promotes nitrogen storage, growthand repair in hard-trained muscles will bemore pronounced than normal. In addition, a noted effect by many athletes polled was that most of them  experienced a joint healing effect during Deca cycles. Since aromatization was low, in 400-600-mg weekly dosages, and fatburning was high due to the high affinity to the androgen recepror that Deca has, anti-estrogens were not typically necessary to avoid gyno and other estrogen induced side effects.

Commonly used doses for men were in the area of  400-600mg weekly, and dosages over 400 mgweekly caused more water retention, while women seemed to do well with 100mgs/week. In fact, women have consistently reported very respectable lean mass and strength gains at dosages of only 50-100 mg weekly. Virilizing effects usually were avoided by single weekly injections of 50-100 mg nandrolone decanoate. Men, however would need to stack Deca with testosterone in order to have more appreciable weight gains, and avoid sexula dysfunction.  Unfortunately, this compound is






 


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