medication to induce heat cycle - Page 2

decoyD, If a 4 year old bitch who never been into heat... they should be spayed.. Why would anybody take the risk of brining this problem into the female puppies genetically? If somebody who really want to breed and to "improve" the "health" in the GSD should breed to a female who doesn't have any health problems. Thats just in my opinion.

I agree, the drug most commonly used is Cabergoline and Alizine it does more harm than good when it is given to the bitches some are affected mentally, shyness, aggression,smaller litters, appetite is affected. I started this so that people are aware that it is practiced alot, It is actually a side affect that the bitch comes in to heat.I am not a breeder so I do not use this but top U.S breeders are using this for higher profit, more bitches in heat more money

I have never seen nor heard of any proof that a bitch who hasnt come in season naturally, would pass that problem to any of her female offspring. GSD breeders do not have a monopoly on using PG600. In fact I doubt if hardly any have even heard of PG600. It is used much more with other breeds like Greyhounds and Pitbulls. If one has an ACE bitch of any breed that does not come in, and her blood is rare and needed, it is up to the female's owner to decide and not anyone else. PG600 is nothing at all like Cabergoline or Alizine. I would love to see any documentation of any type that shows either of these 2 drugs bring on a heat? Both of these drugs are Tumor reducers. Cabergoline is used for Parkinsons disease and Alizine is used in Europe to Abort pregnancies in Canines. It can be used anytime up to day 45 for termination. Alizine is used for induction of parturition(Labor). It is also used to prevent pregnancy. If a dog was on Alizine it could come in season, but would not produce eggs to be fertilized. I cannot see how these Anti Progestins could bring on a heat. They are for just the opposite.

Like I said it is a side affect and if given for a period of 2-3 weeks the bitch will come into heat. The medication does work but it is harmfull.

Evaluation of Cabergoline and Buserelin Efficacy for Oestrous Induction in the Bitch A Rota1, A Mollo1, L Marinelli2, G Gabai2 and L Vincenti3 Contents The purpose of this work was to compare two different protocols of oestrous induction, using either a dopamine agonist (cabergoline) or a GnRH agonist (buserelin) in anoestrus bitches. The clinical trial involved 22 Beagle bitches, randomly allotted to two treatment groups: group A (n = 12) was orally administered cabergoline (Galastop®; Centralvet-Vetem, Milan, Italy; 5 g/kg SID), until the onset of cytological oestrus or for a maximum of 30 days and group B (n = 10) was treated with buserelin acetate, (Suprefact®; Aventis Pharma, Milan, Italy), administered subcutaneously t.i.d., at 1.5 g/kg for 11 days and 0.75 g/kg for the following 3 days. Blood samples were collected twice a week to measure progesterone and prolactin concentration. Both cabergoline and buserelin produced a significant early decline in prolactin concentration (p < 0.01), but the effect of cabergoline lasted longer. Progesterone concentration was significantly affected by buserelin administration, showing a significant increase (p < 0.01) from day 3 to day 6 of treatment. Cabergoline confirmed its effectiveness in inducing oestrus as 10 of 12 bitches responded to the treatment, were mated and whelped. On the contrary, oestrus was observed in only three of 10 buserelin-treated bitches and in two of them 7 and 13 days after the end of treatment. These same two bitches accepted mating and conceived. The results suggest that in a clinical setting, dopaminergic treatment is the treatment of choice as it yields more consistent results and involves a much easier administration protocol.

I have a small dog about five pounds and get not get a recommended dose and if one dose is enough for pg600.

Edited to remove link: decoyD medication to induce heat cycle (0 replies) 29 Apríl 2005 - 15:04 Reply PG600 is a combo of pregnant mare serum and hCG. A 5 dose packet is under $30 and 1 dose is all that is needed. Interesting drug this Cabergoline, but at $139 for 8 tabs, and in the Italy test, 1 tab given up to 30days until the onset of cytological oestrus doesnt seem practical. I still cannot see where the other drug you posted Alizine is used for anything other than to abort or prevent pregnancy. A study was carried out between April 1997 and October 1998 to determine the effect of the progesterone antagonist, Aglépristone (Alizine), for the prevention of pregnancy. 93 bitches were treated, because of mismating, with Aglépristone. The owners were then contacted 2 weeks and 6 to 12 months after treatment to gather any information on effects noted over this period. The major questions were, was pregnancy prevented and if so what side effects were observed, if any, and whether any metropathies were diagnosed. Also noted was the beginning of the next heat and, if the bitch was mated, the fertility rate. Pregnancy was seen in only one bitch. In 51 bitches minor side effects, either singularly or in combination, such as a transient itch, vaginal discharge, reduced appetite, tiredness or attachment were observed. The fertility was not influenced by the treatment andthe incidence of metropathies was unchanged. Descriptors: contraception, contraceptive agents, dogs, estrenes, female, hormone antagonists, pregnancy, progesterone

I have a small dog about five pounds and can not get a recommended dose of pg600 and if one dose is enough for pg600.

Is pg 600 really safe

I dont know what the dosage would be fora 5lbs dog. i think you are looking on the wrong board to find out if it is safe. you wont find much if any studies of PG600 on dogs, and id be willing to say very few folks here have a lot of experience w/ it (have used it in25 + times). Ive found (as decoyd mentioned) that pitbull and greyhound folks use it a lot. you would most likely have to look in those circles to find someone who as used it multiple times for a answer based on expereince vs emotion or hear-say