SV to Reinstate Long Coats in 2010 - Page 12

The purpose of Hardy Weinberg principle isn't to measure number of alleles or diversity of a locus. It is simply to determine expected frequencies of two alleles at a given locus.

That's what I'm asking, can HWE measure a locus that has more than two possible alleles?

There's no way that a single breed could have a higher genetic diversity than a collective group including that breed. 

I would disagree, for example, in the case of isolated populations. But it is a very good point to make, that it is unknown whether the samples taken were from american line, german line, czech line, showline, workingline, DDR line, or a line rumored to have been crossed with mals, wolves, or what have you, or how related these samples may have been to each other..

"That's what I'm asking, can HWE measure a locus that has more than two possible alleles?"

You couldn't do more than two alleles in one calculation but you could do separate calculations for each allele paired with the wild type I suppose.  You would then have distinct HW assessments for each allele.  But the whole point of using SNPs for HW calculation is that they have only two alleles per locus, presumably to make the process simple.

"I would disagree, for example, in the case of isolated populations."

I can't see how it would be possible in any population.  If you include the the whole gene complement of the first sample (say Min Poodle) and add it too the rest of the group (Standard and Toy) you have to be increasing the gene diversity.  There's no way it could be any different.

"But it is a very good point to make, that it is unknown whether the samples taken were from american line, german line, czech line, showline, workingline, DDR line, or a line rumored to have been crossed with mals, wolves, or what have you, or how related these samples may have been to each other.."

Yes, it does seem that in certain breeds/groups, the more diverse the phenotype, the more likely there is to be high disequilibrium.  The study does indicate a strong negative correlation between diversity and HWE.

"I can't see how it would be possible in any population."

Ok, I've had a rethink.  There is a possible way, though it's very, very unlikely to occur in reality.  But I would like to hear your proposition first Daryl

My immediate line of thought was, the data is not useful for myself if it doesn't exclude the showlines, as I have little intention of utilizing them in my breeding.  I would like to see figures that take into consideration the subsets we use, sort of how OFA hip results represent the entire breed, but many would suspect the showlines to be higher contributors of HD.

There's a useful context for any information, and I won't discuss it, if I'd quit getting asked about it.  Next thing y'know, this'll be a thread about my spelling mistakes!  Start a new thread, and go from there.

And as this thread relates to long-coats and any possible loss in genetic diversity were they eliminated, how is any of it relevant?~Speaknow

Diversity is NOT important for this breed's future, PRIORITIZED breeding is.  HWE samples on a few gsd's of unspecified population "pockets", is totally useless information.  So why carry on about it, anyway?