Thanks Jenni, my vet also said to wait before vaccinating the others, though I am not sure yet how long.  In fact I am getting quite paranoid about vaccinations as I was revising some notes and last last time I had sick puppies was in 2008, a brother and sister got a viral infection with bloody diarrhea - again this was about 5 days after their last vaccination (this time it was their third one and the puppies were a little older).  The infection was not as severe, the male was better in a couple of days, the female caused more problems as she recovered quickly initially but then developed a bacterial infection and took a long to time to recover fully, but it was never as bad as this time.   I had two more litters in 2009 and 2010 with no health problems, but the fact that twice puppies have become sick within a few days of the vaccinations is worrying,  a few years ago a friend also lost 6 out of 7 puppies to parvo, having just vaccinated them a few days before.

To answer Keith, who suspected parvo from the start, I did not suspect this initially as on the first day the puppy did not have diarrhea or a raised temperature and I at first related the illness to whatever had caused the yelping at first.  Only on the second night she had diarrhea then went to the vet first thing on Monday.  Next time any puppy becomes sick very suddenly I guess its best to suspect possible parvo from the outset.

Here is some very controversial, but very interesting research on parvo. The tone is a bit radical, but there are some points in there that are hard to argue with.
http://www.freewebs.com/englishshepherds/parvo%20hysteria.pdf
 
Another study:
 http://www.vin.com/proceedings/Proceedings.plx?CID=WSAVA2002&PID=2618 
 

"Next time any puppy becomes sick very suddenly I guess its best to suspect possible parvo from the outset."

Several years ago, on new years eve no less, a friend called me and told me that her bitch who had been in heat five or six weeks before had discharge coming from her vagina.  She was otherwise healthy and active.  I told her to get the dog to the vet immediately and have her checked for pyometra and not to wait since the next day was a holiday.  Sure enough, she had pyometra and was scheduled for immediate surgery.  The vet was baffled, however, as to why she brought the dog in since most people would not have until the dog was noticably sick and she had never seen a dog brought in when the condition was in such an early stage...my friend told the vet that an anal friend of hers insisted on it.  I always envision the worst possible scenario based on the symptoms and act accordingly.  I would rather be relieved that it wasn't as bad as I thought than sorry I waited too long.


Again, sorry about your pup; hope the others stay healthy. 

Hell yes, Keith is right. It's ALWAYS better to pay an unneccessary vet bill (though it's cheap peace of mind!) than wait and potentially jeopardize the health/life of the dog when it's something like pyo or parvo.

I found a great link recently that had a chart of symptoms it's ok to wait on and ones that need to be addressed immediately...I can't find it now. GRRR.

 Oso, how old are the puppies, again? I'm curious about your vaccination protocol. 

The puppies that got sick are now just short of 3 months, the other two are 10 days younger. I usually give the vaccinations  at approx 6 weeks, 9-10 weeks and 12-14 weeks, the second litter were a little delayed with theirs as this litter got off to a slow start when the mother could not feed them, the mother of the first litter actually reared them in the end.  At 6 weeks they were smaller than usual and I waited until around 7.5 weeks, they were due for the second one around now but as the others got sick I have not done it... The other two had been vaccinated just 5 days before the first one became sick, and previously when they were 6.5 weeks old.

Six weeks is too young for the first shot. All that happens is your vaccination cancels out the natural immunity from the mother. Don't give the first shot until 9-10 weeks. This means that either the puppy buyers have to get them done themselves, or they can bring them to you for the first shots. Here is a really good protocol, the so-called "Dodds Protocol."

Age of Pups	Vaccine Type
9 - 10 weeks   14 weeks   16 -18 weeks (optional)   20 weeks or older, if allowable by law   1 year   1 year	Distemper + Parvovirus, MLV (e.g. Intervet                                       Progard Puppy DPV) Same as above   Same as above (optional)   Rabies   Distemper + Parvovirus, MLV   Rabies, killed 3-year product (give 3-4 weeks apart from distemper/parvovirus booster)

[oh incidentally, all but two parvo shot brands have been failing lately. I forget the name of one, but the other is Intervet. Try to get that one.]

I agree about timelines; I don't vaccinate mine before they go at 8wks for that reason.

The schedule oso used is the typical vet recommended one. Yech.

Neopar??? Is that what you're thinking of, Jackie?

One little thing that may not be exactly accurate is that the vaccine cancels out their immunity; from all I can find, it's more a problem of the body being busy either fighting the vaccine and the real thing sneaks in and knocks them down, OR, the maternal antibodies defeat the vaccine and all you're left with is the adjuvant, which can be harmful and stressful to the pup's body all by itself, even discounting the injection of the virus particles.

Yeah that is probably better worded, Jenn. But I cannot remember the other vaccination brand that is ok, because I was busy being grateful that the brand I used was OKed by the vet. 

We are also seeing something out here on the west coast that is like a sort of...half-case of parvo? All my dogs went thru it after I had a foster from the dreaded Los Angeles County shelter. Either that or it is a really nasty parvo and my dogs were pretty much ok because they had the right kind of shots and only got a mild case. Everybody got really bad diarrhea and vomiting for about five days, lost some weight, and then suddenly got over it.

Then I shipped that dog back east, and all that person's dogs got it too. Jeeze.

Dr. Broadhurst's theories are controversial in Veterniary Medicine.  There is no research that shows Tamiflu is beneficial in the treatment of parvoviral infections in dogs, only anecdotes.  The concern about resistence, as noted in my original post, isn't with regards to Parvo, but in human influenza.  Tamiflu is excreted unchanged in feces and ends up in our waterways through run off and sewage where waterfowl live. Guess what waterfowl carry?  We all need to be cautious about the innappropriate use of medications resulting in the creation of superbugs.  Look at the huge problem MRSAs represent to public health right now.  Save the money you would spend on Tamiflu and invest it in good supportive care, IV fluids, antibiotics to control the secondary infections resulting from translocation of bacteria across the damaged intestinal epithelium, and antiemetics to control vomiting.  With GOOD supportive care most puppies can and do recover from parvo without Tamiflu.