Breeding a Mega Esophagus Carrier

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by Blitzen on 11 August 2012 - 00:08

The dogs I remember with adult onset ME also had MG and I think one was hypothyroid.

by DenWolf on 11 August 2012 - 04:08

Quoted from the same website, under "success stories"...

"The genetic analysis found clear chromosomal association for three of the diseases. Pituitary dwarfism was found to be strongly associated with a region of chromosome 9 that contains a plausible candidate gene – LHX3. Degenerative myelopathy was strongly associated with two regions on chromosome 31, near a previously identified point mutation, and also potentially with a region on chromosome 10. Finally, congenital megaesophagus was associated with a whole block of mutations on chromosome 12."

Link to the article:

http://www.akcchf.org/research/success-stories/hunting-for-hereditary.html

by jaggirl47 on 11 August 2012 - 04:08

I have read that article as well. It is very informative. EPI has also been found on chromosome 12.

by Rik on 11 August 2012 - 05:08

The link Blitzen posted:
".......ME results indicate that the disease is not inherited in an autosomal recessive fashion........."

CU study suggests it can be autosomal recessive.

Still nothing concrete, but hopefully they are getting closer.

by jaggirl47 on 11 August 2012 - 05:08

When I spoke with Clemson directly the other day, they found that it does affect an area in chromosome 12 and it is definitively genetic. They said it has several things pointing to autosomal recessive but the difficulty in pinpointing the exact area make it seem autosomal dominant with incomplete penetrance. So, the official word is there is still no answer.

by Rik on 11 August 2012 - 17:08

This has been an informative and interesting thread.

Current research, though inconclusive, suggests this can be a dominant gene, passed on by one parent. So back to the OP and question. A breeding produces a Mega-E. Is everyone still of the same opinion they started out with.

curious,
Rik

by jaggirl47 on 11 August 2012 - 18:08

Rik,
I am still of the same opinion and will remain this way until there is a genetic test. :)

I am glad we can all have this discussion and look at the issue head on without the normal fighting.

by crhuerta on 11 August 2012 - 21:08

I am absolutely firm in my opinion also....

by jaggirl47 on 12 August 2012 - 15:08

When I get any updates on ME testing, I will be sure to post it for everyone. Hopefully Clemson will get a new grant and be able to continue the investigations.

by B.Andersen on 11 September 2012 - 17:09

Excellent post Jaggi. Very infomative. On a note the only dog I have had come up as a DM Carrier that was of without West German influence of all Czech descent was a Hobby daughter that was line bred 5 /4 on Ciro Z PS as the dog in question is bred 4/4 on Ciro. Anyway excellent and informative post about genetic markers.

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