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by Czech DDR Lover on 06 October 2011 - 15:10
Blackthorne..can you elaborate on the meaning from your last post?
by gagsd4 on 06 October 2011 - 19:10
DM as ALS: http://www.pnas.org/content/106/8/2794.full
by BlackthornGSD on 06 October 2011 - 20:10
Here's some brief info:
Dogs that have clinical signs and a confirmed diagnosis of DM have tested as genetically affected. A relatively high percentage of dogs in several breeds (including Boxers, Pembroke Welsh Corgis, Chesapeake Bay Retrievers and Rhodesian Ridgebacks) have the predisposing mutation. It is important to note that there are a large number of dogs that have tested as genetically affected, but are reported as clinically normal by their owners. It may be that many of these dogs will develop clinical signs as they get older or it is possible that symptoms will never manifest in these dogs. Research is still needed to determine the frequency of the mutation in breeds known to have DM (German Shepherd Dogs, Rhodesian Ridgebacks, Pembroke and Cardigan Welsh Corgis, Boxers, Chesapeake Bay Retrievers, Standard Poodles). In the future, we may identify other risk factors in those dogs that have tested as genetically affected. Wise use of this test can reduce the incidence of dogs at risk for DM in the long-term, particularly if other low frequency risk factors are identified that can more easily be reduced. It is likely to take many generations to reduce the frequency of this disease in breeds with higher frequency of the mutation.
http://www.caninegeneticdiseases.net/DM/ancmntDM.htm
Basically, the current thinking is that there are two genetic sources of DM in dogs (in GSDs at least). One (let's call it, "Type 1 DM") has been identified and a DNA test can be done to see what genes the dogs carry.
But it is looking like there is a second genetic cause for DM in dogs (we can call it "Type 2 DM") and that dogs who test clear with the current DNA test may still get this 2nd type (because scientists have not yet identified the responsible genes). Also, because not all dogs who have a pair of genes for Type 1 DM get the disease, it is likely that there is some other factor that turns "on" the DM in those dogs who end up affected.
Because most of the research for the DNA test for DM was done on Corgis, it's possible that the Type 1 DM is very common in Corgis and uncommon in GSDs and that Corgis do not get Type 2 DM ever and that Type 2 DM may be the more common type in GSDs. The problem right now is that we just don't know.
Nevertheless, it can only be a positive thing to avoid producing dogs with 2 genes for Type 1 DM--at the least we can reduce the number of those genes in the pool and remove the possibility that our dogs will get this particular problem.
I don't know that there would be any reason at all to test Huskies for this problem--if the breed doesn't have the mutation (it's not mentioned as an at-risk breed anywhere, is it?), they should all be neg/neg.
Dogs that have clinical signs and a confirmed diagnosis of DM have tested as genetically affected. A relatively high percentage of dogs in several breeds (including Boxers, Pembroke Welsh Corgis, Chesapeake Bay Retrievers and Rhodesian Ridgebacks) have the predisposing mutation. It is important to note that there are a large number of dogs that have tested as genetically affected, but are reported as clinically normal by their owners. It may be that many of these dogs will develop clinical signs as they get older or it is possible that symptoms will never manifest in these dogs. Research is still needed to determine the frequency of the mutation in breeds known to have DM (German Shepherd Dogs, Rhodesian Ridgebacks, Pembroke and Cardigan Welsh Corgis, Boxers, Chesapeake Bay Retrievers, Standard Poodles). In the future, we may identify other risk factors in those dogs that have tested as genetically affected. Wise use of this test can reduce the incidence of dogs at risk for DM in the long-term, particularly if other low frequency risk factors are identified that can more easily be reduced. It is likely to take many generations to reduce the frequency of this disease in breeds with higher frequency of the mutation.
http://www.caninegeneticdiseases.net/DM/ancmntDM.htm
Basically, the current thinking is that there are two genetic sources of DM in dogs (in GSDs at least). One (let's call it, "Type 1 DM") has been identified and a DNA test can be done to see what genes the dogs carry.
But it is looking like there is a second genetic cause for DM in dogs (we can call it "Type 2 DM") and that dogs who test clear with the current DNA test may still get this 2nd type (because scientists have not yet identified the responsible genes). Also, because not all dogs who have a pair of genes for Type 1 DM get the disease, it is likely that there is some other factor that turns "on" the DM in those dogs who end up affected.
Because most of the research for the DNA test for DM was done on Corgis, it's possible that the Type 1 DM is very common in Corgis and uncommon in GSDs and that Corgis do not get Type 2 DM ever and that Type 2 DM may be the more common type in GSDs. The problem right now is that we just don't know.
Nevertheless, it can only be a positive thing to avoid producing dogs with 2 genes for Type 1 DM--at the least we can reduce the number of those genes in the pool and remove the possibility that our dogs will get this particular problem.
I don't know that there would be any reason at all to test Huskies for this problem--if the breed doesn't have the mutation (it's not mentioned as an at-risk breed anywhere, is it?), they should all be neg/neg.
by Czech DDR Lover on 07 October 2011 - 02:10
Blackthorn
I haven't seen any research saying anything about a type 2 DM.
DO you have a link to the testing info regarding that?
I Would like more information on the subject of DM type 2.
by Czech DDR Lover on 07 October 2011 - 02:10
I do agree with you that there is no related need to test the Husky for the DM gene since it is not a breed designated as at risk for carrying the abnormal DM gene.
by BlackthornGSD on 07 October 2011 - 04:10
I don't have definitive info about the 2nd possible type of DM. I do know of someone whose dog was DNA tested negative for DM. Yet he got sick with something that seemed to match DM. A 2nd DNA test was done--still negative. Friend contacted the DNA testing researchers and on the dog's death, they did a spinal biopsy--the dog did indeed have degeneration of the myelin sheath--diagnosed positive for DM. This is apparently not the only such case--so it's new research that is opening up.
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