The blood brain barrier in dogs... health related dangers Degenerative Myleopathy - Page 1

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bubbabooboo

by bubbabooboo on 29 May 2016 - 22:05

A good summary of the blood brain barrier and how it protects or does not protect your dog from injury or disease due to pesticides, drugs, and other health threats.  Even dogs without the MDR-1 genetic mutation may have a compromised blood brain barrier due to injury or diseases.  Hypothyroidism has been found to compromise the blood brain barrier allowing toxic substances to cross the barrier and affect the nervous system or infect the dog's brain. 

http://www.dailydogdiscoveries.com/dogs-blood-brain-barrier/

http://www.brainfacts.org/brain-basics/neuroanatomy/articles/2014/blood-brain-barrier

Dangerous leaks

When the blood-brain barrier breaks down, as is the case in some brain cancers and brain infections or when tiny ruptures to blood vessels occur, some substances that are normally kept out of the brain gain entry and cause problems for the brain.

Some evidence suggests the weakening of the blood-brain barrier may even precede, accelerate, or contribute to a number of neurodegenerative disorders. For instance, studies suggest a leaky blood-brain barrier allows too many white blood cells into the brains of people with multiple sclerosis (MS). With access to the brain, these cells attack myelin, the insulating coating between nerve cells, leading to the disease’s devastating symptoms.  Degenerative myleopathy in dogs is closely related to both MS and ALS inhumans.  Drugs, pesticides, and chemicals which weaken or attack the blood brain barrier could contribute to neurologic problems including mimicing and contributing to MS and ALS in humans and DM in dogs ( especially for those dogs with one or more MR-1 mutation ).  There has been a genetic mutation found in dogs which is similar to that present in humans with ALS.  There has also been a correlation between high lattitude ( Vitamin D ) and MS in humans.

http://www.news-medical.net/news/2009/01/21/45208.aspx






 


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