DM testing - Page 4

Out of a love for this breed that spans decades, we test for DM and proudly promote the practice for all breeders. Its affordable, so lets put an end to DM, it is possible within a short few generations if everyone gets on board. Appleridge

So have their been dogs that were afflicted with DM in German shepherds and they tested positive for the gene? Have their been the opposite where the dog has it but no sign of the gene? I know we can argue science points but I am just curious. How many gsd dogs, not all breeds but gsd' s have had both the test and come down with the disease?

Check offa.org for statistics

I have been asking this for years now and and so far none is still the answer. Duke I don't do top secret... honest, and very few know the line i have seen it in mix's. Blitzen no pedigree and no conformation has been produced so far from this question. It does not appear to effect anywhere near the same percentage has any another line. In fact Im still waiting for one. If thats the case then research should be why those numbers are so drastically off percentage wise. There would be something beneficial there.

it is not for me to write other breeders stuff on here, they were breeding carrier to carrier and untested to carrier, so are looking for problems, we make sure if we have carrier to breed it to clear, and in fact did that recently and tested all pups, all clear and one carrier in that litter
this can and will happen in any line, west, czech, showline whatever

the minimum we can do is test our breedingmaterial and use our brains a bit

Gigante, if the owners of all suspected DM dogs don't have the dogs posted at death , how would they know if their dogs are free of DM or not?  If they don't talk about it, how would anyone know and don't even tell me that there aren't breeders who won't admit they have/had a dog/s with issues that might have been DM. How many GSD's with "back injuries" are put down and never posted? Owners and breeders of certain lines, show and working, have convinced themselves their dogs can't be involved so they ignore the testing. If there are uneffected lines, then OFA et al needs to know that as it may indicate a significant mutation.

Just because YOU haven't seen a pedigree on a working line dx'd with DM sure doesn't mean they don't exist. It only means you haven't seen one.

In breeds where inbreeding and linebreeding is practiced routinely, it might be possible for certain lines to avoid specific entities like DM. However, given the avoidance of linebreeding and inbreeding in GSD's it seem very unlikely that any line can remain free of any genetic disease for more than one generation. DNA testing  GSD's for DM will probably never become obsolete.

 

 

Dont close your eyes but test on HD, ED, DM and dwarfism.

I did it with my stud Yoshyi vom Haus Dexel !
He has HD-normal, ED-normal, DM free and Dwarfism free!

For the future I only want a pup who is free from DM and dwarfism
 

The DM in Corgis and GSD are not the same form of the DM disease or defect. The genetic test developed is not accurate for all types of DM. There exists familial DM ( genetic but rare ) and sporadic DM ( not genetic but the vast majority ). Lumping all DM together for all breeds is just stupid and is not based on science. Correlation does not prove causation is one of the laws of science that seems to be ignored by the OFA when it's suits their financial and organizational goals. I have spent a great deal of time explaining that DM like ALS ( the human form of a similar disease ) is not primarily genetic nor is it caused by one gene variant ( SOD1 ). No matter how many times the OFA and those willing to believe the current DM test is valid for the GSD as a breed want to say it .. that will not make it true. That is why the SV and the European GSD breeders do not use the DM genetic test based on the SOD1 mutation because they know the test is not valid for the GSD. For those wanting to improve hips and reduce diseases in their GSD I suggest feeding a raw meat based diet consisting of animal protein and fats from birth to death. This will do more to improve HD, ED, and DM as well as other diseases than all of the veterinarians and OFA will ever accomplish.

http://www.instituteofcaninebiology.org/degenerative-myelopathy.html

First Chart breeds with less than 50 dogs tested  .. Second chart breeds with more than 50 dogs tested  .. Pit Bulls, Collies and Australian Shepherds have a higher incidence of the SOD1 mutation than do GSD .. Mountain Curs have the SOD1 mutation at twice the rate of the GSD.

Everyone already knows that, Bubba. It's been posted here many times. I assume you don't test your dogs for DM and that is one of the reasons you don't?

I'm with you, Rico.