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ForumsGerman Shepherd Dog > Interesting article on DM (24 replies)
Interesting article on DM by Gwenith on 22 April 2012 - 18:25 |
| This article was sent to me by another GSD owner. http://www.chessieinfo.net/degenerative-myelopathy.htm First time I have ever seen any mention of it being suspected of being polygenetic. No publication by Dr. Coates thus far has clearly mentioned this suspicion. I also find it very interesting that 90% of fox terriers test "at risk", but non have never developed DM. I am aware that Dr. Coates and team is working on releasing a new publication. Hopefully it will give insight to all these updated extremely important findings. Gwen |
by Abby Normal on 22 April 2012 - 18:53 |
Interesting article. I believe that the possibility of it being polygenic has been mentioned and the possibility of other genes being involved has never been ruled out. In fact UofM have said if 'genetic or environmental modifiers exist we want to find them' The article it links to refers to researchers @ the Broad Instatute searching for modifier genes, particularly in the disparity in age of onset of early age vs very late age. |
Abby Normal by Gwenith on 22 April 2012 - 19:26 |
| Abby I so agree. But I have never seen mention of it possibly being polygenetic. I know this sounds weird but beginning to wonder if the SOD1 is the protective gene rather than the gene responsible for causing DM. I am no scientist. I know they are working hard. I do think the fix terriers should be looked at. Why they never develope DM and yet carry the double mutation. What gene do they have that is protecting them? Surely everyone with beloved breeds wants a cure or at least medication that will prolong the disease. I happen to be owned by 2 breeds. Pembrokes and my GSD that I believe has DM even though his DM DNA status is "carrier". He is 13 years 4 months. Nothing will happen for my Blade. But my 9 year old "at risk" corgi maybe, something will be discovered. Gwen |
by Gwenith on 23 April 2012 - 16:28 |
| I have have extremely serIous doubts the Chessie people wrote this on their own. I am fairly certain this was aided by one of Dr. Coates team. This is not just mere speculation on their part but something that has been given to them to post on their Web page. JMHO, of course. Too much technical and research data there to have been published by the the Chessie Club all alone. Gwen |
by joanro on 23 April 2012 - 18:38 |
| Until the actual cause is discovered, OFA is raking in the bucks and creating a false sense of security for people buying into the screening program. |
by Gwenith on 23 April 2012 - 21:25 |
| That is the problem I have. I don't think the OFFA should be making a single dime until every mutated gene is isolated as well as triggers for what causes full blown DM. I would be much happier if they would just discover a way to confirm DM in living dogs. Heck with the gene, confirm this in living dogs. I hate that the only way to confirm DM is via necropsy during a very emotional state of mind. I can see offa doing hips and elbows and rating them as good, excellent, borderline. This test at this point is premature in my opinion. and people do seem to have an overly false sense of security especially when it comes to dogs that have tested "clear". Obviously several breeds and several dogs that were clear have come back now with confirmed DM upon necropsy. Which to me means it is time the offa removes it from their site. It can be made available via Univ. of Missouri. JMO. Gwen |
by beetree on 23 April 2012 - 21:31 |
| No one is forcing anyone to test Gwen. It is what it is; it is all there is at this time. You guys are nuts if you think anyone is getting rich off of this test. I think what it does and doesn't do has been explained oh, umpteen times. |
beetree by Gwenith on 23 April 2012 - 22:07 |
| Why the "name calling"? Is there no way to state opinions in this country anymore without childish name calling? I tested ALL 3 of the dogs. I am NOT the person that brought up the money being made. I never said anyone was getting rich. Snow me in my post where I said offa was getting rich. I said they shouldn't benefit. Last I checked "freedom of speech" still exists in this country. But it is close to changing. That's even quite obvious on this forum. Nuts?? I just love when people resort to childish name calling. It gives me a thrill. Gwen |
by Blitzen on 23 April 2012 - 22:08 |
| Test your breeding dogs, don't test your breeding dogs, up to you. Until something better comes along I will test mine. The rest of you can do what you want. There are plenty of buyers who won't know enough to ask and/or who don't care, so there will always be buyers. |
Blitzen by joanro on 23 April 2012 - 22:15 |
| I think OFA makes money from their testing/ screening programs. They don't do it for free. No matter how cheap a test is, the numbers accumulate.......bee, you're free to call people "nuts" and we ,likewise, are free to voice our opinion. |
by Gwenith on 23 April 2012 - 22:25 |
| I don't breed. Don't agree with breeding. Too many dogs dying unnecessarily in shelters. Breed away Blitzen. All my dogs have been tested on my buck and not one of them are ever going to breed. I will test but I wouldn't test to make a breeding decision. I have email from Dr. Coates and Dr. Tonomura at Broad Institute sent to me last Friday. Gwen |
by beetree on 23 April 2012 - 22:28 |
| No problem Joanro. The money is peanuts, but okay if you and more think otherwise. Just that I think it is more to the point, so what? What do you think they do with this bumper crop of a profit? Probably help with more research? Wow, damn criminal of them! |
by Blitzen on 23 April 2012 - 22:29 |
| Blitzen doesn't 'breed away" Gwen. I just bred my first GSD litter yesterday and have been in dogs since 1969. |
by Gwenith on 23 April 2012 - 22:34 |
| Hey thanks Joan! You are correct. That numbers and amount does add up. I could go into offa database right now. Calculate every dog that has been tested and come back with an exact amount made thus far. No one said a word about getting rich. But they are benefitting off of a test that has flaws. Including a "clear" GSD, a clear Chessie and a "clear" Berner. How many dogs haven't been necropsied? Think about that! More people don't do it or won't for emotional reasons than do it. So who knows really how many clears actually had DM upon death? No one! Not even Dr. Coates. Not any researcher. Because the majority will not follow through with necropsy. Gwen |
by Blitzen on 23 April 2012 - 22:35 |
| Test don't test...no one is forcing you to do either. |
by beetree on 23 April 2012 - 22:36 |
| LOL@Gwen. Would you feel better if I said you gals think like nuts? Get real, and get your big girl panties on. |
by Blitzen on 23 April 2012 - 22:41 |
| I guess I just don't get it, Bee. Testing for DM is not a requirement for registering a litter with AKC or the SV. Ergo it is optional. What's the big freaking deal? |
by beetree on 23 April 2012 - 22:53 |
| Blitzen, that would be the $64,000 dollar question, wouldn't it? |
by Blitzen on 23 April 2012 - 22:56 |
| Indeed........ |
by Gwenith on 23 April 2012 - 23:51 |
| More little girl pathetic liberal name calling. Go for it. Makes you feel good. The only ones needing big girl panties on are the ones calling names. Enjoy your games. It becomes more amusing to me by the minute. I don't know how many times I have to say all 3 of my dogs have been tested. With my money. But it sure wasn't to claim breed worthiness. Since the test has flaws and Dr. Coates's email that I have in my "in box" stated that. So have fun with your name calling. The last laugh will be on you in about 10 years. Shrug I tested. Never told anyone on this forum not to test. I wouldn't rely on it for breeding. But I would never breed. Hey ya wanna sell a puppy to a Nut like me. Can't imagine how you screen puppy buyers. Not in this day and time. Gwen |
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