ProHeart 6 ... FDA and drug companies too cozy - Page 1

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bubbabooboo

by bubbabooboo on 28 May 2016 - 17:05

When ProHeart 6 ( moxidectin injectible ) came on the market as a prescription only treatment for heart worms a local vet talked my wife into giving our GSD an injection. Within minutes the female GSD ( 6 years old ) was throwing up and sick. We had never seen her throw up before so we were concerned and called the vet. The vet said it was "normal" and nothing to be concerned about. You can bet that our report of an adverse reaction was never reported as Fort Dodge and our vet had just charges $70 for less than 70 cents worth of Moxidectin at the retail price the drug is sold for and used in sheep.  A huge profit margin for Moxidectin made it a potential cash cow for both vets and Fort Dodge ( a subsidiary of Wyeth then ). 

The heroine of this story is Dr. Victoria Hampshire who revealed the deaths, diseases, and adverse effects that ProHeart 6 was responsible for in dogs and the scope of the problem was likely ten to 100 times worse than what she knew as many of the complaints were reported by pet owners to veterinarians making profits on ProHeart 6 who did not forward the complaints to the FDA due to conflict of interest.

ProHeart 6 was later withdrawn from the market due to the adverse effects and deaths it caused. The fact that Wyeth Pharmaceutical and Fort Dodge waged a smear campaign and tried to have the veterinarians and whistle blowers within the FDA fired for exposing the adverse effects and deaths ProHeart 6 caused and that the product was recalled but never had it's registration cancelled should serve as a sober reminder to all pet owners that the FDA and pet food and pet drug makers have a very cozy and mutually beneficial relationship. A link below outlines the events in the ProHeart recall and the depths of collusion and political power the pet food and pet drug makers have within the FDA and government.

Background

Dr. Hampshire worked for the FDA’s Center for Veterinary Medicine (CVM), where she reviewed the safety of various animal care drugs, including Wyeth’s ProHeart6. The drug was initially approved by the FDA in 2001 to treat heartworm in canines. By 2004, ProHeart6 claimed sales of over $35 million. The problem, as Dr. Hampshire discovered, was that the drug was related to liver problems, autoimmune disease, severe seizures, and over 500 dog deaths. The FDA pressed Wyeth to recall the drug, which it did in September 2004.

But Wyeth was merely stalling – it set out to gain re-approval for its profitable drug from an FDA Advisory Committee, slated to meet in late January 2005.

https://en.wikibooks.org/wiki/Professionalism/Victoria_Hampshire_and_Lester_Crawford

http://www.dogster.com/doggie-style/victoria-hampshire-a-real-hero-who-took-on-drug-giant-wyeth-over-killer-drug-proheart-6

https://www.whistleblower.org/proheart6

http://bewareofproheart6.freecyberzone.com/

ProHeart6 remains on the market to this day .. and the makers continue to lie about the safety of this product.

 

 


bubbabooboo

by bubbabooboo on 30 May 2016 - 01:05

By 2004 Wyeth and Fort Dodge reported sales of 17 million doses of ProHeart6 at an average price of $60 per dose plus the veterinarian gets a cut of the profits and an office visit fee for each injection. Wyeth and veterinarians had grossed over one billion dollars from an antiquated and cheap to make wormer (fermentation product). The cost for a single dose of moxidectin for use in sheep and cattle was a tiny fraction for the cost of the product used in dogs. Wyeth and veterinarians were willing to turn a deaf ear to complaints and dog deaths for a billion dollar cash cow product.

"Over the course of the past three years, however, the FDA has received 5,913 adverse events reports about the drug from veterinarians and dog owners. According to the FDA, many of these reports involved life-threatening events, such as anaphylaxis, convulsions, hematopoetic disorders, and hepatopathies—about 616 reports involved deaths. The FDA has also evaluated a number of reports involving neurologic problems and cardiac signs."

The results stated above do not take into account that veterinarians ( as mine did ) swore that any adverse effects up to and including death were unrelated to ProHeart6 and that every adverse reaction was the first time they had ever seen such an effect in their office or heard about.  Likely the number of deaths were 20X to 50X reported to FDA as most reports were filtered through veterinarians and their offices or went directly to Fort Dodge and not to the FDA.

The cost of moxidectin in cattle is $145 for 500 ml of 1% ai material or $145 for 5 g ai moxidectin technical product.  The use rate in dogs for ProHeart6 is 0.0773 mg/lb. of weight for each dog.  At the dose rate in dogs $145 of moxidectin as sold in cattle will treat ( 5000 mg in 5 g ai / 0.0773 ) 64,683 pounds of dogs at a retail cost of $145 for 1000 sixty five pound dogs ( 15 cents per dog  for a $60 or more per dog injection cost twice per year plus vet fees for office visits).  Perhaps that will help those reading understand the motives, profits and money involved with the ProHeart6 adverse effects, veterinarian profits, and Wyeth Pharmaceutical profits.


srfwheat

by srfwheat on 30 May 2016 - 07:05

Thank you for the valuable information and research on ProHeart6.

bubbabooboo

by bubbabooboo on 01 June 2016 - 12:06

Another story on the FDA being in bed with Industry and drug makers.  Dangerous and toxic products obtain registration and those registrations are never withdrawn.  Flame retardants ( a majot toxic chemical for pets), Paxil and Vioxx are additional examples of toxic products which obtained registration within the FDA due to insider conflict of interest and fraud within FDA.

http://articles.mercola.com/sites/articles/archive/2016/06/01/industry-money-unsafe-products.aspx?utm_source=dnl&utm_medium=email&utm_content=art1&utm_campaign=20160601Z1&et_cid=DM107057&et_rid=1508882825

 

http://www.centerforhealthjournalism.org/2015/10/20/flame-retardants-paxil-perceptions-%E2%80%9Csafety%E2%80%9D-often-come-industry






 


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